Azathioprine Side Effects in Patients with Ocular Manifestations of Behçet’s Syndrome

Introduction: Behçet’s syndrome (BS) is a systemic vasculitis characterized by skin involvement, uveitis, and arthritis. Azathioprine is an effective therapy among other immunosuppressive drugs for this disease but there is no clear data about all aspects of its side effects in BS patients with ocular manifestations. we want to determine the prevalence and types of adverse effects related with azathioprine in ocular BS patients. Methods: the study is  cross-sectional with ۱۶۵ confirmed diagnosis of BS patients who had ocular involvement. Data were collected retrospectively with medical records of the BS clinic. Results: Of ۱۶۵ enrolled patients, Adverse events of treatment with azathioprine occurred in ۱۱ patients (۶.۶۷%). side effects included: elevated of liver enzymes in four patients (۲.۴۳%), hypersensitive reaction in ۲ patients (۱.۲۱%), leukopenia in ۲ patients (۱.۲۱%), nausea in ۱ patient (۰.۶۱%), skin tumor in ۱ patient (۰.۶۱%), and t pancreatitis and hepatitis in one patient (۰.۶۱). Conclusion: azathioprine reduced the rate of adverse effects and resolution of the ocular manifestations in patients with BS and has few side effects so, it is good choice to treat patients with BS.

کلیدواژه ها:

Azathioprine ، Behçet’s syndrome ، Uveitis ، Side Effects